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"The Care Bears Battle the Freeze Machine is the second television special to feature the Care Bears characters. Made by Ottawa's Atkinson Film-Arts studios, it premiered in syndication in April 1984. The special introduces two new Care Bears characters, Hugs and Tugs. Plot Paul, a young boy, vows to get even with his bullies. Through this, the mad scientist Professor Coldheart tricks him into fixing his "Careless Ray Contraption" after his bumbling henchman Frostbite breaks it by accident. The Care Bears, led by Tenderheart Bear, must do all that they can to stop Coldheart's plan of freezing every child in town with his machine. Hugs and Tugs, two baby Care Bears are kidnapped by Coldheart to be trapped in ice, and after finding it out from their caretaker Grams Bear, the Care Bears must not only stop Coldheart and convince Paul not to get even, but must also rescue Hugs and Tugs. Overview The special, a follow-up to the previous installment The Land Without Feelings (from 1983), sees the return of the ten original Bears and the rarely seen Cloud Keeper, as well as the blue-skinned love-hating villain Professor Coldheart. In addition, the special introduces Baby Hugs, Baby Tugs, their caretaker Grams Bear, and Professor Coldheart's dwarf henchman, Frostbite. Release and reception The Care Bears Battle the Freeze Machine aired on over 100 U.S. TV stations in April 1984, and was sponsored by the Kenner company. That same year, it won an award for Best Children's Program at the 13th National ACTRA Awards. A tie-in book based on the special () was written by Arthur S. Rosenblatt, illustrated by Joe Ewers and published by Parker Brothers as a part of the Tales from the Care Bears series. The special was released on VHS and Beta by Family Home Entertainment in May 1984. This, and The Land Without Feelings, were among the ten best-selling children's videos on the U.S. market in 1985. It was released for the first time on DVD, as a special feature, on MGM Home Enteratainment's 2007 re-issue of The Care Bears Movie. The print featured on the disc is the syndicated edit, not the original broadcast version. In 1987, Don R. Le Duc referred to Freeze Machine as a "shallow merchandising marvel". References External links 1984 television films 1984 films Animated television specials Canadian television specials Care Bears films 1980s children's animated films 1980s musical films Musical television specials "
"Metharbital was patented in 1905 by Emil Fischer working for Merck.US Patent 782742 It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy.The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). It has similar properties to phenobarbital. History * 1952 Gemonil was introduced by Abbott Laboratories. * 1990 Abbott stopped marketing. Synthesis Metharbital can be synthesized from 2,2-diethylmalonic acid and O-methylisourea.A. Halpern, J.W. Jones, J. Am. Pharm. Assoc., 38, 352 (1949) References Anticonvulsants Barbiturates GABAA receptor positive allosteric modulators AbbVie brands "
"Tremis attributed to Audeca. Audeca or Andeca () was the last Suevic King of Galicia from 584 until his deposition in 585. He deposed Eboric and usurped the throne by marrying the young king's mother, Siseguntia (or Sisegutia), the widow of Eboric's father and predecessor, Miro. He consigned Eboric to a monastery. This action gave the Visigothic king Leovigild an excuse to invade the Suevic kingdom, which he did in 585. According to John of Biclar, "Leovigild devastated Galicia, deprived the captured King Audeca of his rule, and brought the people, treasure, and territory of the Suevi under his own power. He made Galicia a province of the Goths."John of Biclar, Chronicon, 73, in Arias, p. 32. John goes on to say that he "tonsured [Audeca] and dignified [him] with the honour of the priesthood, after having held that of the kingship."John of Biclar, Chronicon, 76, in Arias, p. 32. The deposed usurper was relegated to the city of Beja. To Isidore of Seville, his deposition meant the end of the Suevic kingdom, which had lasted 177 years from Isidore's starting point of 408: "the kingdom which they [the Sueves] held in idle lethargy, they have now lost at an even more shameful cost, although it may seem quite amazing that they had managed to retain up to the present day that which they have now given up without any show of resistance."Isidore, Historia Suevorum, 68, in Arias, pp. 32-33. After Audeca, the Suevic kingdom ceased to exist, but one pretender, Malaric, briefly led opposition to the Visigoths. A coin bearing the inscription ODIACCA REIGES (probably "King Odiacca") has been identified as one belonging to the reign of Audeca. The sole known coin of the type was kept in Madrid and lost in 1936. The only other Suevic king to mint coins bearing his name that have survived to this day is Rechiar.Grierson and Blackburn, MEC, p. 79. Notes Sources *Arias, Jorge C. Identity and Interactions: The Suevi and the Hispano-Romans University of Virginia, Spring 2007. *Grierson, Philip, and Blackburn, Mark. Medieval European Coinage, with a Catalogue of the Coins in the Fitzwilliam Museum, Cambridge, vol. 1, The Early Middle Ages (5th–10th Centuries). Cambridge University Press, 1986. 6th-century Suebian kings "